Comparative pathology of rhesus macaque and common marmoset animal models with Middle East respiratory syndrome coronavirus
Identifieur interne : 000E53 ( Main/Exploration ); précédent : 000E52; suivant : 000E54Comparative pathology of rhesus macaque and common marmoset animal models with Middle East respiratory syndrome coronavirus
Auteurs : Pin Yu [République populaire de Chine] ; Yanfeng Xu [République populaire de Chine] ; Wei Deng [République populaire de Chine] ; Linlin Bao [République populaire de Chine] ; Lan Huang [République populaire de Chine] ; Yuhuan Xu [République populaire de Chine] ; Yanfeng Yao [République populaire de Chine] ; Chuan Qin [République populaire de Chine]Source :
- PLoS ONE [ 1932-6203 ] ; 2017.
Descripteurs français
- KwdFr :
- ARN viral, Animaux, Callithrix (physiologie), Callithrix (virologie), Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Hybridation in situ, Immunohistochimie, Infections à coronavirus (anatomopathologie), Infections à coronavirus (diagnostic), Inflammation, Macaca mulatta (physiologie), Macaca mulatta (virologie), Macrophages alvéolaires (métabolisme), Modèles animaux de maladie humaine, Poumon (virologie), Réplication virale, Spécificité d'espèce.
- MESH :
- anatomopathologie : Infections à coronavirus.
- diagnostic : Infections à coronavirus.
- métabolisme : Macrophages alvéolaires.
- physiologie : Callithrix, Macaca mulatta.
- virologie : Callithrix, Macaca mulatta, Poumon.
- ARN viral, Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Hybridation in situ, Immunohistochimie, Inflammation, Modèles animaux de maladie humaine, Réplication virale, Spécificité d'espèce.
English descriptors
- KwdEn :
- Animals, Callithrix (physiology), Callithrix (virology), Coronavirus Infections (diagnosis), Coronavirus Infections (pathology), Disease Models, Animal, Humans, Immunohistochemistry, In Situ Hybridization, Inflammation, Lung (virology), Macaca mulatta (physiology), Macaca mulatta (virology), Macrophages, Alveolar (metabolism), Middle East Respiratory Syndrome Coronavirus, RNA, Viral, Species Specificity, Virus Replication.
- MESH :
- chemical : RNA, Viral.
- diagnosis : Coronavirus Infections.
- metabolism : Macrophages, Alveolar.
- pathology : Coronavirus Infections.
- physiology : Callithrix, Macaca mulatta.
- virology : Callithrix, Lung, Macaca mulatta.
- Animals, Disease Models, Animal, Humans, Immunohistochemistry, In Situ Hybridization, Inflammation, Middle East Respiratory Syndrome Coronavirus, Species Specificity, Virus Replication.
Abstract
Middle East respiratory syndrome (MERS), which is caused by a newly discovered coronavirus (CoV), has recently emerged. It causes severe viral pneumonia and is associated with a high fatality rate. However, the pathogenesis, comparative pathology and inflammatory cell response of rhesus macaques and common marmosets experimentally infected with MERS-CoV are unknown. We describe the histopathological, immunohistochemical, and ultrastructural findings from rhesus macaque and common marmoset animal models of MERS-CoV infection. The main histopathological findings in the lungs of rhesus macaques and common marmosets were varying degrees of pulmonary lesions, including pneumonia, pulmonary oedema, haemorrhage, degeneration and necrosis of the pneumocytes and bronchial epithelial cells, and inflammatory cell infiltration. The characteristic inflammatory cells in the lungs of rhesus macaques and common marmosets were eosinophils and neutrophils, respectively. Based on these observations, the lungs of rhesus macaques and common marmosets appeared to develop chronic and acute pneumonia, respectively. MERS-CoV antigens and viral RNA were identified in type I and II pneumocytes, alveolar macrophages and bronchial epithelial cells, and ultrastructural observations showed that viral protein was found in type II pneumocytes and inflammatory cells in both species. Correspondingly, the entry receptor DDP4 was found in type I and II pneumocytes, bronchial epithelial cells, and alveolar macrophages. The rhesus macaque and common marmoset animal models of MERS-CoV can be used as a tool to mimic the oncome of MERS-CoV infections in humans. These models can help to provide a better understanding of the pathogenic process of this virus and to develop effective medications and prophylactic treatments.
Url:
DOI: 10.1371/journal.pone.0172093
PubMed: 28234937
PubMed Central: 5325479
Affiliations:
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Human Disease Comparative Medicine, Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, 5 Panjiayuan Nanli, Chaoyang District, Beijing, People’s Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, 5 Panjiayuan Nanli, Chaoyang District, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xu, Yanfeng" sort="Xu, Yanfeng" uniqKey="Xu Y" first="Yanfeng" last="Xu">Yanfeng Xu</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, 5 Panjiayuan Nanli, Chaoyang District, Beijing, People’s Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, 5 Panjiayuan Nanli, Chaoyang District, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Deng, Wei" sort="Deng, Wei" uniqKey="Deng W" first="Wei" last="Deng">Wei Deng</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, 5 Panjiayuan Nanli, Chaoyang District, Beijing, People’s Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, 5 Panjiayuan Nanli, Chaoyang District, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Bao, Linlin" sort="Bao, Linlin" uniqKey="Bao L" first="Linlin" last="Bao">Linlin Bao</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, 5 Panjiayuan Nanli, Chaoyang District, Beijing, People’s Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, 5 Panjiayuan Nanli, Chaoyang District, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Huang, Lan" sort="Huang, Lan" uniqKey="Huang L" first="Lan" last="Huang">Lan Huang</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, 5 Panjiayuan Nanli, Chaoyang District, Beijing, People’s Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, 5 Panjiayuan Nanli, Chaoyang District, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xu, Yuhuan" sort="Xu, Yuhuan" uniqKey="Xu Y" first="Yuhuan" last="Xu">Yuhuan Xu</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, 5 Panjiayuan Nanli, Chaoyang District, Beijing, People’s Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, 5 Panjiayuan Nanli, Chaoyang District, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yao, Yanfeng" sort="Yao, Yanfeng" uniqKey="Yao Y" first="Yanfeng" last="Yao">Yanfeng Yao</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, 5 Panjiayuan Nanli, Chaoyang District, Beijing, People’s Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, 5 Panjiayuan Nanli, Chaoyang District, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, 5 Panjiayuan Nanli, Chaoyang District, Beijing, People’s Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, 5 Panjiayuan Nanli, Chaoyang District, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Callithrix (physiology)</term><term>Callithrix (virology)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (pathology)</term><term>Disease Models, Animal</term><term>Humans</term><term>Immunohistochemistry</term><term>In Situ Hybridization</term><term>Inflammation</term><term>Lung (virology)</term><term>Macaca mulatta (physiology)</term><term>Macaca mulatta (virology)</term><term>Macrophages, Alveolar (metabolism)</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>RNA, Viral</term><term>Species Specificity</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral</term><term>Animaux</term><term>Callithrix (physiologie)</term><term>Callithrix (virologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Humains</term><term>Hybridation in situ</term><term>Immunohistochimie</term><term>Infections à coronavirus (anatomopathologie)</term><term>Infections à coronavirus (diagnostic)</term><term>Inflammation</term><term>Macaca mulatta (physiologie)</term><term>Macaca mulatta (virologie)</term><term>Macrophages alvéolaires (métabolisme)</term><term>Modèles animaux de maladie humaine</term><term>Poumon (virologie)</term><term>Réplication virale</term><term>Spécificité d'espèce</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Macrophages, Alveolar</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Macrophages alvéolaires</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Callithrix</term><term>Macaca mulatta</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Callithrix</term><term>Macaca mulatta</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Callithrix</term><term>Macaca mulatta</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Callithrix</term><term>Lung</term><term>Macaca mulatta</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Immunohistochemistry</term><term>In Situ Hybridization</term><term>Inflammation</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Species Specificity</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ARN viral</term><term>Animaux</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Humains</term><term>Hybridation in situ</term><term>Immunohistochimie</term><term>Inflammation</term><term>Modèles animaux de maladie humaine</term><term>Réplication virale</term><term>Spécificité d'espèce</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome (MERS), which is caused by a newly discovered coronavirus (CoV), has recently emerged. It causes severe viral pneumonia and is associated with a high fatality rate. However, the pathogenesis, comparative pathology and inflammatory cell response of rhesus macaques and common marmosets experimentally infected with MERS-CoV are unknown. We describe the histopathological, immunohistochemical, and ultrastructural findings from rhesus macaque and common marmoset animal models of MERS-CoV infection. The main histopathological findings in the lungs of rhesus macaques and common marmosets were varying degrees of pulmonary lesions, including pneumonia, pulmonary oedema, haemorrhage, degeneration and necrosis of the pneumocytes and bronchial epithelial cells, and inflammatory cell infiltration. The characteristic inflammatory cells in the lungs of rhesus macaques and common marmosets were eosinophils and neutrophils, respectively. Based on these observations, the lungs of rhesus macaques and common marmosets appeared to develop chronic and acute pneumonia, respectively. MERS-CoV antigens and viral RNA were identified in type I and II pneumocytes, alveolar macrophages and bronchial epithelial cells, and ultrastructural observations showed that viral protein was found in type II pneumocytes and inflammatory cells in both species. Correspondingly, the entry receptor DDP4 was found in type I and II pneumocytes, bronchial epithelial cells, and alveolar macrophages. The rhesus macaque and common marmoset animal models of MERS-CoV can be used as a tool to mimic the oncome of MERS-CoV infections in humans. These models can help to provide a better understanding of the pathogenic process of this virus and to develop effective medications and prophylactic treatments.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al-Rabeeah</name></author><author><name 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Linlin" uniqKey="Bao L" first="Linlin" last="Bao">Linlin Bao</name><name sortKey="Bao, Linlin" sort="Bao, Linlin" uniqKey="Bao L" first="Linlin" last="Bao">Linlin Bao</name><name sortKey="Deng, Wei" sort="Deng, Wei" uniqKey="Deng W" first="Wei" last="Deng">Wei Deng</name><name sortKey="Deng, Wei" sort="Deng, Wei" uniqKey="Deng W" first="Wei" last="Deng">Wei Deng</name><name sortKey="Huang, Lan" sort="Huang, Lan" uniqKey="Huang L" first="Lan" last="Huang">Lan Huang</name><name sortKey="Huang, Lan" sort="Huang, Lan" uniqKey="Huang L" first="Lan" last="Huang">Lan Huang</name><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><name sortKey="Xu, Yanfeng" sort="Xu, Yanfeng" uniqKey="Xu Y" first="Yanfeng" last="Xu">Yanfeng Xu</name><name sortKey="Xu, Yanfeng" sort="Xu, Yanfeng" uniqKey="Xu Y" first="Yanfeng" last="Xu">Yanfeng Xu</name><name sortKey="Xu, Yuhuan" sort="Xu, Yuhuan" uniqKey="Xu Y" first="Yuhuan" last="Xu">Yuhuan Xu</name><name sortKey="Xu, Yuhuan" sort="Xu, Yuhuan" uniqKey="Xu Y" first="Yuhuan" last="Xu">Yuhuan Xu</name><name sortKey="Yao, Yanfeng" sort="Yao, Yanfeng" uniqKey="Yao Y" first="Yanfeng" last="Yao">Yanfeng Yao</name><name sortKey="Yao, Yanfeng" sort="Yao, Yanfeng" uniqKey="Yao Y" first="Yanfeng" last="Yao">Yanfeng Yao</name><name sortKey="Yu, Pin" sort="Yu, Pin" uniqKey="Yu P" first="Pin" last="Yu">Pin Yu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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